ECUACION DE HENDERSON - HASSELBACH PDF

The dependance of many reactions, as well as biological functions depends upon the pH of the solution in which the chemistry occurs. We will see examples below where we will be able to calculate the pH of a solution of a chemical by knowing its pKa and ratio of ionized and unionized chemical. The pKa of a chemical in solution- The pKa of a solution determines the acidity of the compound. The pKa also determines the amount of ionization of a molecule in a solution of particular pH.

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The dependance of many reactions, as well as biological functions depends upon the pH of the solution in which the chemistry occurs. We will see examples below where we will be able to calculate the pH of a solution of a chemical by knowing its pKa and ratio of ionized and unionized chemical. The pKa of a chemical in solution- The pKa of a solution determines the acidity of the compound. The pKa also determines the amount of ionization of a molecule in a solution of particular pH.

Below are a few examples of calculating the pKa of a molecule using the Henderson-Hasselbalch equation. Keeping in mind that the Henderson-Hasselbalch equation is useful in these three scenarios, lets take a look at certain applications and examples.

Applications and Examples of the Henderson-Hasselbalch equation 1] Calculating pH of a Solution using pKa Knowing the pH of a solution is extremely important for many chemical reactions as well as biological systems such as enzymes and proteins.

Example 1: Calculate the pH of a buffer composed of 0. Step 1. Figure out what variables we have: i. Analyze what we need for the Henderson-Hasselbalch equation i. Thus we only need to convert the Ka into pKa. In this problem we must realize that the final volume is mL and everything must be calculated using that as the final volume. Figure out what variables we have: a mg of Tris was dissolved in a total final volume of mL.

HCl Step 2. Analyze what we need for the Henderson-Hasselbalch equation We already know the pKa of tris i. We need to know the amount of [Tris] and [Tris. When 0. HCl] formed is 0.

This ability is widely used in organic chemistry synthesis, analytical chemistry and pharmaceutical sciences especially in absorption, distribution and excretion properties. The examples below will shed some light of its usefulness. Example 1: Aspirin acetylsalicylic acid has a pKa of 3. Aspirin is a commonly used drug. This problem will help you understand the utility of the Henderson Hasselbalch equation.

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Henderson-Hasselbalch equation is a simple expression which relates the pH, pKa and the buffer action of a weak acid and its conjugate base. The Henderson-Hasselbalch equation also describes the characteristic shape of the titration curve of any weak acid such as acetic acid, phosphoric acid, or any amino acid. The titration curve of a weak acid helps to determine the buffering pH which is exhibited around the pKa of that acid. For example, in the case of acetate buffer, the pKa is 4.

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Ecuación de Henderson-Hasselbach

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